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4 . 2019

The efficiency of branched chain aminoacids (BCAA) in the nutrition of combat sport athletes

Abstract

Balanced nutrition of athletes involves the usage of both ordinary products and complexes of functional food ingredients that contribute to improving the performance of athletes, strengthening the immune system. One of the main components of specialized foods that are widely used in sports’ nutrition and food supplements are branched chain aminoacids (BCAA): valine, leucine, isoleucine.

The aim of the work was to study the effect of the BCAA intake on the parameters of body composition and the immune status of combat sport athletes during the training period. Material and methods. The object of the study was 20 athletes (masters of sports and candidates for masters of sports in combat sports: sambo, judo) at the age of 17-18 years. Athletes were distributed into 2 groups. Athletes of the main group (n=10) for 4 weeks in addition to the main diet were supplemented with BCAA at a dosage of 5 g per day. The athletes of the control group (n=10) received the main diet without BCAA inclusion. Examination of athletes of both groups was carried out at the beginning of the research and after 4 weeks of the observation period. The actual nutrition of athletes and daily energy consumption have been studied, body composition, the quantitative composition of subpopulations of peripheral blood lymphocytes, cytokine profile and hematological parameters have been determined.

Results and discussion. As a result of a comprehensive survey of athletes, the positive effect of BCAA intake on the phase angle value (7.35±0.28 vs 6.41±0.32 at the beginning of the study, p<0.05) and muscle mass (25.1±0.8 vs 23.4±0.6 kg, p<0.10) has been demonstrated. In the control group these parameters did not change statistically significantly (7.05+0.25 vs 6.78+0.42 and 24.1±1.7 vs 23.8±1.5 kg). The athletes of the main group showed an increase in erythrocyte hemoglobin content (30.0±0.3 vs 29.0±0.2 pg, p<0.05). The relative content of basophilic leukocytes in athletes of the main group decreased by the end of the observation period - from 0.69±0.05 to 0.54±0.05% (p<0.05), that indicated an increase of immune resistance. The biomarker of the immunotropic effect of BCAA was the suppression of IL-4 production (1.6±0.1 to 1.3±0.1 pg/ml, p<0.05) synthesized by Th2 lymphocytes, with switching response to cellular immunity.

Conclusion. The results of this study provide evidence of the effectiveness of BCAA usage in sports’ nutrition for maintaining sport performance, immunity, and the adaptive potential of combat sport athletes.

Keywords:combat sport athletes, BCAA, immunity, lymphocytes, cytokines

For citation: Trushina E.N., Vybornov V.D., Riger N.A., Mustafina O.K., во1п1аеуа T.N., Timonin А.Ы., Zilova I.S., Radzhabkadiev R.M. The efficiency of branched chain aminoacids (BCAA) in the nutrition of combat sport athletes. Voprosy pitaniia [Problems of Nutrition]. 2019; 88 (4): 48-56. doi: 10.24411/0042-8833-2019-10041 (in Russian)

References

1. Dmitriev A.V., Gunina L.M. Fundamentals of sports nutrition. Saint Petersburg, 2018: 213 p. (in Russian)

2. Shimomura Y. Nutritionutical effects of branched chain amino acids on skeletal muscle. J Nutr. 2006; 136: 529S-32S.

3. Sheybak V.M. Regulation and pathophysiological importance of metabolism of amino acids with branched hydrocarbon chain. Zdravookhraneniye [Public Health]. 1999; (6): 25-7. (in Russian)

4. Baquet A., Lavoinne A., Hue L. Comparison of the effects of various amino acids on glycogen synthesis, lipogenesis, and ketogenesis in isolated rat hepatocytes. Biochem J. 1991; 273: 57-62.

5. Calder P.C., Newsholme P. Glutamine and the immune system. In: P.C. Calder, C.J. Field, H.S. (eds). Gill Nutrition and Immune Function. Wallingford, New York: CABI Publishing; 2002: 109-132.

6. Meij er A.J. Amino acid regulation of autophagosome formation. Methods Mol Biol. 2008; 445: 89-109.

7. Marc Rhoads J., Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids. 2009; 37: 111-22.

8. Potier M., Darcel N., Tome D. Protein, amino acids, and the control of food intake. Curr Opin. Clin Nutr Metab Care. 2009; 12: 54-8.

9. Vary T.C., Lynch C.J. Nutrient-signaling components controlling protein synthesis in striated muscle. J Nutr. 2007; 137: 1835-43.

10. Rennie M.J., Bohe J., Smith K., et al. Branched-chain amino acids as fuels and anabolic signals in human muscle. J Nutr. 2006; 136: 264-8.

11. Shimomura Y. Exercise promotes ВСАА catabolism: effects of ВСАА supplementation on skeletal muscle during exercise. J Nutr. 2004; 134: 1583S-7S.

12. Kim D.H., Kim S.H., Jeong W.S., Lee H.Y. Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances, and energy metabolism substances. J Exerc Nutr Bio-chem. 2013; 17: 169-80.

13. Contro V., Mancuso E.P., Proia P. Delayed onset muscle soreness (DOMS) management: present state of the art. Trends Sport Sci. 2016; 3: 121-7.

14. Avruch J., Long X., Ortiz-Vega S., et al. Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab. 2009; 296: 592-602.

15. Valovka T., Verdier F., Cramer R., et al. Protein kinase C phos-phorylates ribosomal protein S6 kinase beta II and regulates its subcellular localization. Mol Cell Biol. 2003; 23: 852-63.

16. Wolfe R.R. Branched-chain amino acids and muscle protein synthesis in humans: myth or reality? J Int Soc Sports Nutr. 2017; 14: 30-41.

17. Martinchik A.N., Baturin A.K., Feoktisova A.I., Svyakhovskaya IV. Methodical recommendations for assessing the amount of food consumed by the method of 24-hour (daily) reproduction of food. Approved Deputy Chief State Sanitary Doctor of the Russian Federation G.G. Onishchenko February 26, 1996 No. 0-19/ 14-17. Moscow: Ministry of Health of the Russian Federation, 1996: 124 p. (in Russian)

18. Sorvacheva T.N., Martinchik A.N., Pyrieva E.A. Comprehensive assessment of the actual nutrition and nutritional status of children and adolescents: approved by the decision of the Academic Council of the Russian Medical Academy of Postgraduate Education of the Ministry of Health of Russia on January 28, 2014. (in Russian)

19. Martinchik A.N., Baturin A.K., Bayeva V.S., Peskova E.V., Larina T.I., Zaburkina T.G. Album portions of products and dishes. Moscow: Institut Pitaniya RAMN, 1995: 64 p. (in Russian)

20. The chemical composition of Russian food: a handbook. I.M. Sku-rikhina, V.A. Tutelyan (eds). Mosow: DeLi Print, 2002: 236 p. (in Russian)

21. Frankenfield D., Roth-Yousey L., Compher C. Comparison of predictive equations for resting metabolic rate in healthy nonobese and obese adults: a systematic review. J Am Diet Assoc. 2005; 105: 775-89.

22. Nikityuk D.B., Miroshnikova Yu.V., Burlyaeva E.A., Vybornov V.D., Balandin M.Yu., Timoshenko K.T. Methodical recommendations on nutrition for young athletes. Federal Research Center for Nutrition, Biotechnology and Food Safety. Moscow, 2017: 133 p. (in Russian)

23. Zborovsky A.B., Zborovskaya I.A. Internal diseases in tables and diagrams. Handbook. 3rd edition. In: F.I. Komarov (ed.). Moscow: Meditsinskoe Informatsionnoe Agentstvo, 2011: 668 p. (in Russian)

24. Khaitov R.M. Immunology. Moscow: GEOTAR-Media, 2006: 311 p. (in Russian)

25. Zemskov A.M., Zemskov V.M., Karaulov A.V. Clinical immunology. Moscow: GEOTAR-Media, 2005: 319 p. (in Russian)

26. Khaidukov S.V., Zurochka A.V. Cytometric analysis of T-helper subpopulations (Th1, Th2, Treg, Th17, T-helper activated). Medit-sinskaya immunologiya [Medical Immunology]. 2011; 13 (1): 7-16. (in Russian)

27. Kepshinsky C. A. The role of T-helper types 1 and 2 in the regulation of cellular and humoral immunity. Immunologiya [Immunology]. 2002; (2): 77-9. (in Russian)

28. Yarilin A.A. Symbiotic relationships of cells of the immune system. Immunologiya [Immunology]. 2001; (4): 16-20. (in Russian)

29. Yarilin A.A. Basics of immunology. Moscow: Meditsina, 1999: 607 p. (in Russian)

30. Sugama S., Conti B. Interleukin-18 and stress. Brain Res Rev. 2008; 58: 85-95.

31. Cruzat V.F., Krause M., Newsholme P. Amino acid supplementation and impact on immune function in the context of exercise. J Int Soc Sports Nutr. 2014; 11: 61-8.

32. Calder Р.С. Branched-chain amino acids and immunity. J Nutr. 2006; 136 (1): 288S-93S.

33. Samuelsson H., Moberg M., Apro W., Ekblom B., Blomstrand E. Intake of branched-chain or essential amino acids attenuates the elevation in muscle levels of PGC-1a4 mRNA caused by resistance exercise. Am J Physiol Endocrinol Metab. 2016; 311: E246-51.

34. Maida A., Chan J.S.K., Sjoberg K.A., Zota A., Schmoll D., Kiens B., et al. Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution. Mol Metab. 2017; 6: 873-81.

35. Khedr N.F, Khedr E.G. Branched chain amino acids supplementation modulates TGF-p1/Smad signaling pathway and interleukins in CCl4-induced liver fibrosis. Fundam Clin Pharmacol. 2017; 31: 534-45.

36. Monirujjaman M., Ferdouse A. Metabolic and physiological roles of branched-chain amino acids. Adv Mol Biol. 2014; 2014: ID 364976. 6 p. URL: http://dx.doi.org/10.1155/2014/364976

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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