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4 . 2015

The study of rs1800012 polymorphism of the alpha1- chain collagen type 1 gene in moscow women and children with different level of bone strength

Abstract

The frequency of rs1800012 polymorphism of alpha1-chains of type 1 collagen gene (COL1A1) was studied by real-time PCR in 422 Moscow women and children, including pregnant women (n=96), lactating (n=29) and non-pregnant women (n=28) and preschool children (2–6 years, n=76) and school children (7–16 years, n=193) with different levels of bone strength (BS) as determined by ultrasound densitometry. It was found that the decrease in the value of the BS (Z-score<-1) was observed in 60% of women, 54% of preschool children and 48% of school-aged children. In the surveyed cohort the predominant genotype of rs1800012 polymorphism COL1A1 gene was GG (55.1%), the frequency of the genotype TT – 7.6%, of T-allele – 26.2%. There were no statistically significant relationships of BS with a particular genotype of rs1800012 polymorphism of COL1A1 gene in all examined women. A positive but not statistically significant association of T allele with a risk BS reduction was found in non-pregnant and pregnant women (OR=2.143, p=0.31 and OR=1.227, p=0.55, respectively). For preschool and school-aged children T allele was not associated with the risk of BS reduction. In school-age children a statistically significant inverse association of T allele with the risk of BS reduction was shown (OR=0.621 with p=0.037), available also as a tendency in preschool children.

Keywords:osteoporosis, women, alpha1-chain collagen type 1 (COL1A1) gene, genetic polymorphism, preschoolers, school-aged children, pregnant and lactating women

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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