Effect of probiotic product containing bifidobacteria and biogel from brown algae on the intestinal microflora and parameters of innate immunity in mice with experimental drug dysbacteriosis
AbstractThе article represents the results of studying the effect of a new fermented product (FP) containing the probiotic strain Bifidobacterium bifidum 791 and Biogel from brown algae Laminaria japonica on the composition of intestinal microflora and parameters of innate immunity in mice with experimental dysbacteriosis, induced by administration of gentamicin in dose of 25 mg per kg body weight during 7 days. The experimental animals received for 6 weeks in addition to the diet FP, which was 2% of the average volume of feed intake. The FP influence was manifested by more rapid reduction of dyspepsia symptoms, restoration of body weight and balance the intestinal microbiocenosis (increasing of bifido- and lactobacteria, typical E. coli, reducing of the bacteria genus Proteus and Clostridium, elimination of S. aureus). As the results of FP administration we observed the statistically significant reduction of endogenous intoxication values and increasing of the phagocyte activity of neutrophils, related to effector cells of innate immunity, compared with animals not receiving FP. Identified effects of FP are due to both its probiotic properties through the presence of bifidobacteria and immunomodulating and enteral sorbtion activities of alginate component.
Keywords:probiotic products, probiotics, antibiotic-assotiated dysbiosis, alginate, biogel from brown algae, intestinal microbiocenosis, innate immunity