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1 . 2015

The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region

Abstract1112 people from Moscow region have been surveyed. Genotyping of rs659366 polymorphism UCP2 gene was performed using allele-specific amplification, result detection in real time and using TaqMan-probes complementary DNA polymorphic sites. The study of rs659366 polymorphism of the UCP2 gene has showed that 36,9% of patients had genotype AA, 46,7% – genotype AG, and 16,5% – genotype GG. The frequency of allele A was 60,2%, allele G – 39,8%. BMI, value of fat mass, visceral fat area, serum glucose and triglyceride levels were significantly higher in carriers of A allele in the homozygous and heterozygous state than in carriers of G allele in the homozygous state. Frequency of A allele compared with G allele in obese patients (BMI greater than 30 kg/m 2) was: OR – 1,52; CI (1,24–1,86), p=0,001, and in diabetes mellitus type 2 – OR – 1,22; CI (0,910–1,622), p=0,19.

Keywords:obesity, diabetes mellitus type 2 gene polymorphism rs659366 UCP2

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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