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6 . 2013

Identification of genetic polymorphisms associated with overweight in athletes of winter sports

AbstractThe identification of polymorphisms rs9939609 gene FTO, Trp64Arg ADRB3 and gene -866G> A UCP2 gene using multiplex allele-specific PCR hybridization- fluorescence detection in real time has been carried out in highly skilled athletes under the age of 30 years engaged in biathlon (n=25) and bobsleigh (n=28). The data on the frequency of allele risk of obesity has been obtained. The study of polymorphism rs9939609 of the FTO gene in biathletes found that 30% of them are carriers of the risk allele of obesity (A). Among the bobsledder the frequency of allele A is slightly higher than in European populations and is 55,4%. The study of gene polymorphism Trp64Arg ADRB3 showed that the frequency of risk allele of obesity 64Arg in biathletes (14%) was slightly higher than in the European population and biathletes (5,4%). The results of the identification of polymorphism -866G> A gene UCP2 in biathletes and bobsledders, found the incidence of obesity risk allele, respectively, 52 and 58,7%.

Keywords:obesity risk allele, rs9939609 polymorphism of the gene FTO, Trp64Arg polymorphism of the gene ADRB3, -866G> A polymorphism of the gene UCP2

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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