Identification of genetic polymorphisms associated with overweight in athletes of winter sports
AbstractThe identification of polymorphisms rs9939609 gene FTO, Trp64Arg ADRB3 and gene -866G> A UCP2 gene using multiplex allele-specific PCR hybridization- fluorescence detection in real time has been carried out in highly skilled athletes under the age of 30 years engaged in biathlon (n=25) and bobsleigh (n=28). The data on the frequency of allele risk of obesity has been obtained. The study of polymorphism rs9939609 of the FTO gene in biathletes found that 30% of them are carriers of the risk allele of obesity (A). Among the bobsledder the frequency of allele A is slightly higher than in European populations and is 55,4%. The study of gene polymorphism Trp64Arg ADRB3 showed that the frequency of risk allele of obesity 64Arg in biathletes (14%) was slightly higher than in the European population and biathletes (5,4%). The results of the identification of polymorphism -866G> A gene UCP2 in biathletes and bobsledders, found the incidence of obesity risk allele, respectively, 52 and 58,7%.
Keywords:obesity risk allele, rs9939609 polymorphism of the gene FTO, Trp64Arg polymorphism of the gene ADRB3, -866G> A polymorphism of the gene UCP2