To the content
5 . 2013

Markers of immune inflammation in patients with type 2 diabetes and obesity

AbstractAim: to investigate cytokine profile in patients with type 2 diabetes mellitus (DM) with different degree of obesity. 154 patients with type 2 DM were examined (55,2% women, 44,8% men). All patients received standard antihyperglycemic therapy; mean age was 46,1±0,82 years, mean duration of disease was 7,2±1,43 years. The patients were divided into the following groups according to their degree of obesity: grade I obesity (n=50), grade II obesity (n=51), grade III obesity (n=53). 18 healthy volunteers (38,9% men, 61,1% women, mean age 41,2±3,2 years, BMI – 22,1±1,8 kg/m2). The patients and healthy volunteers were underwent biochemical analysis, determination of the cytokine profile and estimation of TNF-α, IL-1, IL-4, TGF-β1 by enzyme-linked immunosorbent assay. It has been shown that increase of the body weight excess in patients with type 2 DM and obesity is accompanied with elevation of proinflammatory cytokines (TNF-α, IL-1, TGF-β1) along with the reduction of inflammatory cytokines (IL-4). The TNF-α concentration in patients with grade I obesity was 2,8 fold higher than in the comparison group , in patients with grade II and III – 4 and 5,7 fold respectively. A similar trend occurred in TGF-β1 level: 2 fold increase – when I obesity, 3,3 and 4 fold – respectively for grade II and III. Unidirectional dynamic changes of IL-1 in patients with type 2 diabetes reflects 1,3 fold increase in its level under obesity I grade, 1,7 fold – under II degree and 2,2 fold – under III degree compared to the level in the comparison group. IL-4 level in patients with diabetes and obesity is strikingly contrasted with the index of the comparison group and progressively reduced: 1,7 fold – when grade I obesity, 3,6 fold- with grade II, 7,7 fold – in the grade III. The data obtained indicates that cytokine profile play a critical part in pathogenesis of type 2 DM in association with obesity.

Keywords:markers of inflammation, obesity, type 2 diabetes mellitus, cytokine status

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

SCImago Journal & Country Rank
Scopus CiteScore
CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

Journals of «GEOTAR-Media»