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2 . 2013

Effects of omega-3 polyunsaturated fatty acids on antioxidant capacity in rats

AbstractDietary administration of omega-3 polyunsaturated fatty acids (EPA + DHA, 1,2:1) at dose 0,3 or 1 g/kg bw during 4 weeks led to minor (by 14% and 17%, p<0,05) decrease of serum antioxidant capacity and serum level of vitamin E (by 30% and 31%, p<0,05) and the activity of paraoxonase-1 (by 14% at 0,3 g/kg bw, p<0,05). The activity of antioxidant enzymes in liver increasedin a dose-dependent manner. At higher dose of omega-3 polyunsaturated fatty acids a 45% increase in the activity of paraoxonase-1 (p<0,05), 21% – heme oxygenase-1 (p>0,05), 68% – quinone reductase (p<0,05), 19% – glutathione S-transferase (p<0,05) compared to the control group was found. The direct relationship between activities of enzymes and increase of MDA level in liver (by 47 and 107%, p<0,05) was found. Selected doses of omega-3 polyunsaturated fatty acids had no significant effects on total liver antioxidant capacity, microsomes NADPH-Fe2+-induced lipid peroxidation and lysosomal membranes stability.

Keywords:omega-3 PUFA, eicosapentaenoic acid, docosahexaenoic acid, paraoxonase-1, heme oxygenase-1, quinone reductase, glutathione S-transferase, vitamins A and E

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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